Perinatal Exposure to Aroclor 1254 Impairs Distortion Product Otoacoustic Emissions (DPOAEs) in Rats
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چکیده
منابع مشابه
GATA3 haploinsufficiency causes a rapid deterioration of distortion product otoacoustic emissions (DPOAEs) in mice.
Human HDR (hypoparathyroidism, deafness and renal dysplasia)-syndrome is caused by haploinsufficiency of zinc-finger transcription factor GATA3. The hearing loss due to GATA3 haploinsufficiency has been shown to be peripheral in origin, but it is unclear to what extent potential aberrations in the outer hair cells (OHCs) contribute to this disorder. To further elucidate the pathophysiological m...
متن کاملRelationship Between Distortion Product – Otoacoustic Emissions (DPOAEs) and High-Frequency Acoustic Immittance Measures
BACKGROUND Pathologies that alter the impedance of the middle ear may consequently modify the DPOAE amplitude. The aim of this study was to correlate information from 2 different clinical procedures assessing middle ear status. Data from DPOAE responses (both DP-Gram and DP I/O functions) were correlated with data from multi-component tympanometry at 1000 Hz. MATERIAL AND METHODS The subjects w...
متن کاملassessment of the effects of different sound pressure levels on distortion product otoacoustic emissions (dpoaes) in rats
excessive exposure to noise can lead to noise-induced hearing loss. otoacoustic emissions affect the microscopic biomechanical activities of healthy outer hair cells. the present study aimed at assessing the influence of various sound pressure levels on distortion product otoacoustic emissions (dpoaes) in rats. to this end, 27 adult male rats with an age range of 3 to 4 months and a weight of 2...
متن کاملGestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats.
Developmental exposure to polychlorinated biphenyls (PCBs) has been associated with cognitive deficits in children. The current study assessed effects of gestational and lactational exposure to a commercial PCB mixture, Aroclor 1254 (A1254), on spatial learning and memory in rats, using the radial-arm maze (RAM). Pregnant Long-Evans females (10/dose group) were exposed to 0 or 6-mg/kg/day A1254...
متن کاملDistortion product otoacoustic emissions in tinnitus patients.
Tinnitus is a symptom that affects a great number of patients. Its diagnosis, treatment, and follow-up are difficult, owing to its subjectivity. The authors propose the use of distortion product otoacoustic emissions (DPOAEs) in tinnitus evaluation. They studied three groups: controls, having no complaint of tinnitus and normal hearing; group 1, presenting tinnitus and normal audiometry; and gr...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2002
ISSN: 1096-0929
DOI: 10.1093/toxsci/68.2.458